SSR504734 (free base)
SSR504734 free base is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 (IC50=18, 15, and 38 nM, respectively) . SSR504734 free base shows anti-schizophrenia, anti-anxiety and anti-depression activities[1].
Product Specifications
CAS Number
[742693-38-5]
UNSPSC
12352005
Target
GlyT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ssr504734-free-base.html
Smiles
O=C(C1=CC=CC(C(F)(F)F)=C1Cl)NC[C@H]2N(CCCC2)C3=CC=CC=C3
Molecular Formula
C20H20ClF3N2O
Molecular Weight
396.83
References & Citations
[1]Ronan Depoortère, et al. Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology. 2005 Nov;30 (11) :1963-85.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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