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SSR504734 (free base)

SSR504734 free base is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 (IC50=18, 15, and 38 nM, respectively) . SSR504734 free base shows anti-schizophrenia, anti-anxiety and anti-depression activities[1].

Product Specifications

CAS Number

[742693-38-5]

UNSPSC

12352005

Target

GlyT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ssr504734-free-base.html

Smiles

O=C(C1=CC=CC(C(F)(F)F)=C1Cl)NC[C@H]2N(CCCC2)C3=CC=CC=C3

Molecular Formula

C20H20ClF3N2O

Molecular Weight

396.83

References & Citations

[1]Ronan Depoortère, et al. Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology. 2005 Nov;30 (11) :1963-85.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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