Cholesteryl oleate

Cholesteryl oleate is an ester compound formed from Cholesterol (HY-N0322) and Oleic acid (HY-N1446), which is involved in lipid transport, storage and cell membrane formation in living organisms. Cholesteryl oleate may serve as a potential biomarker for prostate cancer. Cholesteryl oleate can also prepare cationic solid lipid nanoparticles (SLNs) for efficient gene silencing[1][2][3][4].

Product Specifications

CAS Number

[303-43-5]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Liposome

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Cholesteryl_oleate.html

Purity

99.0

Solubility

Acetone : 50 mg/mL (ultrasonic)|DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : 12.5 mg/mL (ultrasonic;warming;heat to 50°C)

Smiles

CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Molecular Formula

C45H78O2

Molecular Weight

651.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Souza SL, et al. Study of the miscibility of cholesteryl oleate in a matrix of ceramide, cholesterol and fatty acid. Chem Phys Lipids. 2011 Oct;164 (7) :664-71.|[2]Suñé-Pou M, et, al. Cholesteryl oleate-loaded cationic solid lipid nanoparticles as carriers for efficient gene-silencing therapy. Int J Nanomedicine. 2018 May 30;13:3223-3233.|[3]Li J, et al. Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer. Sci Rep. 2016 Feb 11;6:20984.|[4]Rudel LL, et al. Hepatic origin of cholesteryl oleate in coronary artery atherosclerosis in African green monkeys. Enrichment by dietary monounsaturated fat. J Clin Invest. 1997 Jul 1;100 (1) :74-83.