Levosimendan

Levosimendan (Simsndan; OR-1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.

Product Specifications

CAS Number

[141505-33-1]

Product Name Alternative

Simsndan; OR-1259

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Phosphodiesterase (PDE) ; Potassium Channel

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Levosimendan.html

Purity

99.82

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C1C[C@@H](C)C(C2=CC=C(N/N=C(C#N)/C#N)C=C2)=NN1

Molecular Formula

C14H12N6O

Molecular Weight

280.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Nieminen, M.S., et al., Levosimendan: current data, clinical use and future development. Heart Lung Vessel, 2013. 5 (4) : p. 227-245.|[2]Papp, Z., et al., Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol, 2012. 159 (2) : p. 82-7.|[3]Landoni, G., et al., Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies. Crit Care Med, 2012. 40 (2) : p. 634-46.