Levosimendan
Levosimendan (Simsndan; OR-1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.
Product Specifications
CAS Number
141505-33-1
Product Name Alternative
Simsndan; OR-1259
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Phosphodiesterase (PDE) ; Potassium Channel
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Levosimendan.html
Purity
99.82
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1C[C@@H](C)C(C2=CC=C(N/N=C(C#N)/C#N)C=C2)=NN1
Molecular Formula
C14H12N6O
Molecular Weight
280.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Nieminen, M.S., et al., Levosimendan: current data, clinical use and future development. Heart Lung Vessel, 2013. 5 (4) : p. 227-245.|[2]Papp, Z., et al., Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol, 2012. 159 (2) : p. 82-7.|[3]Landoni, G., et al., Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies. Crit Care Med, 2012. 40 (2) : p. 634-46.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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