DNA/RNA Damage Antibody, Clone 15A3: RPE

DNA and RNA damage are critical molecular events that contribute to the onset and progression of neurodegenerative diseases. These lesions arise from both endogenous metabolic processes and environmental stressors, including oxidative stress, inflammation, and exposure to neurotoxins. In neurons—cells with limited regenerative capacity—such damage can have profound and lasting effects. Reactive oxygen and nitrogen species (RONS), such as hydroxyl radicals and peroxynitrite, induce oxidative modifications to nucleic acids. Key biomarkers of this damage include 8-hydroxyguanine (8-OHG), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and 8-hydroxyguanosine (8-OHG), which are associated with mutagenic base transversions and impaired transcriptional fidelity. These lesions disrupt gene expression, mitochondrial function, and synaptic signaling—hallmarks of neurodegenerative pathology. In diseases such as Alzheimer’s, Parkinson’s, and ALS, persistent DNA and RNA damage activates neuroinflammatory pathways and accelerates neuronal loss. Moreover, the failure of DNA repair mechanisms exacerbates genomic instability, further compromising neural integrity. Understanding the molecular signatures of nucleic acid damage offers valuable insights into disease mechanisms and provides a foundation for developing diagnostic biomarkers and targeted therapies aimed at preserving genomic stability and neuronal function.

Cancer | Oxidative Stress | Cell Signaling | Post-translational Modifications | Oxidation | Cell Signaling | Epigenetics and Nuclear Signaling | DNA/RNA | DNA Damage and Repair

1. Kim H.W., Murakami A., Williams M.V., and Ohigashi H. (2003) Carcinogenesis 24(2): 235-241. 2. Pilger A. and Rudiger H.W. (2006) Int Arch Occup Environ Health. 80(1): 1-15. 3. Malins D.C. and Haimanot R. (1991) Cancer Res. 51(19): 5430-5432. 4. Kvam E. and Tyrrell R.M. (1997) Carcinogenesis 18(11): 2281-2283. 5. Kowluru R.A., Atasi L., and Ho Y.S. (2006) Invest Ophthalmol Vis Sci 47(4): 1594-9. 6. Bowers R. et al. (2004) Am J Respir Crit Care Med. 169(6): 764-9. 7. Cui J., Holmes E.H., Greene T.G., and Liu P.K. (2000) Faseb J. 14(7): 955-67.

1. Kim H.W., Murakami A., Williams M.V., and Ohigashi H. (2003) Carcinogenesis 24 (2) : 235-241. 2. Pilger A. and Rudiger H.W. (2006) Int Arch Occup Environ Health. 80 (1) : 1-15. 3. Malins D.C. and Haimanot R. (1991) Cancer Res. 51 (19) : 5430-5432. 4. Kvam E. and Tyrrell R.M. (1997) Carcinogenesis 18 (11) : 2281-2283. 5. Kowluru R.A., Atasi L., and Ho Y.S. (2006) Invest Ophthalmol Vis Sci 47 (4) : 1594-9. 6. Bowers R. et al. (2004) Am J Respir Crit Care Med. 169 (6) : 764-9. 7. Cui J., Holmes E.H., Greene T.G., and Liu P.K. (2000) Faseb J. 14 (7) : 955-67.