LAMP1 Antibody, Clone Ly1C6: APC

Mouse Anti-Rat LAMP1 Monoclonal IgG1

Product Specifications

Background

LAMP1 (Lysosome-Associated Membrane Protein 1) is a key structural component of the lysosomal membrane, playing a central role in lysosomal stability, autophagy, and immune signaling. Expressed primarily in late endosomes and lysosomes, LAMP1 is involved in intracellular trafficking and the degradation of cellular waste. In neurodegenerative diseases such as Alzheimer’s and Parkinson’s, LAMP1 dysregulation is associated with impaired autophagic flux, lysosomal dysfunction, and neuroinflammation. Aberrant localization of LAMP1, due to mutations in its carboxyl-terminal tyrosine-based motif (YXXI), disrupts lysosomal targeting and contributes to cellular stress. Additionally, LAMP1 is implicated in mast cell activation and inflammatory responses, promoting leukocyte adhesion and potentially exacerbating neuroinflammatory cascades. As a biomarker of lysosomal integrity and glial activation, LAMP1 offers insight into the lysosomal-autophagy axis in neurodegeneration and represents a promising target for therapeutic intervention.

CAS Number

9007-83-4

Specifications

Detects ~120kDa.

Product Name Alternative

LAMP1, Lysosome-associated membrane glycoprotein 1, CD107a, CD107, LAMPA, LGP120, IgpA, CD107 antigen-like family member A, 120 kDa lysosomal membrane glycoprotein, Lamp-1

Synonyms

LAMP1 Antibody, Clone Ly1C6: APC

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

25328

Swiss Prot

P14562

Accession Number

NP_036989.1

Cellular Locus

Cell Membrane | Endosome | Lysosome | Endosome membrane | Lysosome membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat,Hamster

Immunogen

Rat liver lysosomal membrane preparations

Target

LAMP1

Clonality

Monoclonal

Isotype

IgG1

Clone

Ly1C6

Conjugation

APC

Type

Monoclonal

Applications

WB | ICC/IF | IP

Validated Applications

IHC,ICC/IF

Field of Research

Purification

Protein G Purified

Limit Of Detection

1 µg/ml was sufficient for detection of LAMP1 in rat liver miscrosome by ECL immunoblot analysis.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:1000) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Grutzkau, A. et al (2004) Cytometry A. 61(10): 62-68. 2. Furuta, K. et al. (1999) EMBO J. 17(5):1304-14. 3. Rohrer, J. et al. (1996) J Cell Biol. 132(4): 565-76. 4. Kannan, K., et al. (1996) Cell Immunol. 171: 10-19. 5. Lewis, V., et al. (1985) J. Cell Biol. 100: 1839-1847. 6. Jones, K.A., et al. (2004) Exp Cell Res 295(2): 512-524.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Specificity

Detects ~120kDa.

Background Reference 01

1. Grutzkau, A. et al (2004) Cytometry A. 61 (10) : 62-68. 2. Furuta, K. et al. (1999) EMBO J. 17 (5) :1304-14. 3. Rohrer, J. et al. (1996) J Cell Biol. 132 (4) : 565-76. 4. Kannan, K., et al. (1996) Cell Immunol. 171: 10-19. 5. Lewis, V., et al. (1985) J. Cell Biol. 100: 1839-1847. 6. Jones, K.A., et al. (2004) Exp Cell Res 295 (2) : 512-524.