LAMP1 Antibody, Clone Ly1C6

LAMP1 (Lysosome-Associated Membrane Protein 1) is a key structural component of the lysosomal membrane, playing a central role in lysosomal stability, autophagy, and immune signaling. Expressed primarily in late endosomes and lysosomes, LAMP1 is involved in intracellular trafficking and the degradation of cellular waste. In neurodegenerative diseases such as Alzheimer’s and Parkinson’s, LAMP1 dysregulation is associated with impaired autophagic flux, lysosomal dysfunction, and neuroinflammation. Aberrant localization of LAMP1, due to mutations in its carboxyl-terminal tyrosine-based motif (YXXI), disrupts lysosomal targeting and contributes to cellular stress. Additionally, LAMP1 is implicated in mast cell activation and inflammatory responses, promoting leukocyte adhesion and potentially exacerbating neuroinflammatory cascades. As a biomarker of lysosomal integrity and glial activation, LAMP1 offers insight into the lysosomal-autophagy axis in neurodegeneration and represents a promising target for therapeutic intervention.

LAMP1, Lysosome-associated membrane glycoprotein 1, CD107a, CD107, LAMPA, LGP120, IgpA, CD107 antigen-like family member A, 120 kDa lysosomal membrane glycoprotein, Lamp-1

1. Grutzkau, A. et al (2004) Cytometry A. 61(10): 62-68. 2. Furuta, K. et al. (1999) EMBO J. 17(5):1304-14. 3. Rohrer, J. et al. (1996) J Cell Biol. 132(4): 565-76. 4. Kannan, K., et al. (1996) Cell Immunol. 171: 10-19. 5. Lewis, V., et al. (1985) J. Cell Biol. 100: 1839-1847. 6. Jones, K.A., et al. (2004) Exp Cell Res 295(2): 512-524.

1. Grutzkau, A. et al (2004) Cytometry A. 61 (10) : 62-68. 2. Furuta, K. et al. (1999) EMBO J. 17 (5) :1304-14. 3. Rohrer, J. et al. (1996) J Cell Biol. 132 (4) : 565-76. 4. Kannan, K., et al. (1996) Cell Immunol. 171: 10-19. 5. Lewis, V., et al. (1985) J. Cell Biol. 100: 1839-1847. 6. Jones, K.A., et al. (2004) Exp Cell Res 295 (2) : 512-524.