FKBP51 Antibody, Clone Hi51B

Mouse Anti-Human FKBP51 Monoclonal IgG1

Product Specifications

Background

FKBP51 (FK506-binding protein 5) is a co-chaperone of the Hsp90 complex and a key regulator of glucocorticoid receptor sensitivity, stress response, and protein folding. In the brain, FKBP51 modulates neuronal plasticity, inflammation, and tau protein stability—factors central to neurodegenerative disease progression. Elevated FKBP51 expression has been observed in Alzheimer’s disease and is associated with increased tau aggregation and impaired autophagy. Its role in stress hormone signaling also links FKBP51 to mood disorders and cognitive decline, making it a molecular bridge between chronic stress and neurodegeneration. Targeting FKBP51 offers a novel approach to modulate stress-related neurotoxicity and restore proteostasis in aging and diseased brains.

CAS Number

9007-83-4

Specifications

Detects ~51kDa.

Product Name Alternative

AIG6, FK506 binding protein 5, FKBP5, FKBP54, HSP90 binding immunophilin, p54, Pplase, Ptg10, Rotamase, T cell FK506 binding protein

Synonyms

FKBP51 Antibody, Clone Hi51B

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

2289

Swiss Prot

Q13451

Accession Number

NP_001139247.1

Cellular Locus

Cytoplasm | Nucleus

Host

Mouse

Species Reactivity

Human,Mouse,Rat,Rabbit,Dog,Hamster

Immunogen

Recombinant human FKBP51 fragment

Target

FKBP51

Clonality

Monoclonal

Isotype

IgG1

Clone

Hi51B

Conjugation

Unconjugated

Type

Monoclonal

Applications

WB | ICC/IF

Validated Applications

WB,ICC/IF

Field of Research

Cancer | Heat Shock | Cell Signaling | Protein Trafficking | Nuclear Import/Export

Purification

Protein G Purified

Limit Of Detection

A 1:2000 dilution was sufficient for detection of FKBP51 in ~50 µg total protein using WB analysis.

Concentration

1 mg/ml

Dilution

WB (1:2000), ICC/IF (1:1000) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Cheung-Flynn J., Roberts P.J., Riggs D.L., and Smith D.F.(2003) J. Biol. Chem. 278(19): 17388-17394. 2. Davies T.H., Ning Y.N., and Sanchez E.R. (2002) J Biol. Chem. 277 (7): 4597-4600. 3. Wu B. et al. (2004) Proc. Natl. Acad. Sci. USA. 101(22): 8348-8353. 4. Denny W.B., Prapapanich V., Smith D.F., and Scammell J.G. (2005) Endocrinology 146(7): 3194-3201. 5. Hubler T.R. et al. (2003) Endocrinology 144(6): 2380- 2387.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects ~51kDa.

Background Reference 01

1. Cheung-Flynn J., Roberts P.J., Riggs D.L., and Smith D.F. (2003) J. Biol. Chem. 278 (19) : 17388-17394. 2. Davies T.H., Ning Y.N., and Sanchez E.R. (2002) J Biol. Chem. 277 (7) : 4597-4600. 3. Wu B. et al. (2004) Proc. Natl. Acad. Sci. USA. 101 (22) : 8348-8353. 4. Denny W.B., Prapapanich V., Smith D.F., and Scammell J.G. (2005) Endocrinology 146 (7) : 3194-3201. 5. Hubler T.R. et al. (2003) Endocrinology 144 (6) : 2380- 2387.