HO-1 Antibody, Clone 1F12-A6

Heme oxygenase-1 (HO-1), also known as heat shock protein 32, is an inducible enzyme that catalyzes the degradation of heme into biliverdin, free iron, and carbon monoxide—each with distinct biological functions. Biliverdin is rapidly converted to bilirubin, a potent antioxidant, while carbon monoxide acts as a signaling molecule with anti-inflammatory and vasodilatory properties. Free iron, although potentially toxic, is sequestered by ferritin to limit oxidative damage. HO-1 is strongly upregulated in response to oxidative stress, inflammation, and neurotoxic insults, positioning it as a key cytoprotective factor in the central nervous system. Its expression is elevated in various neurodegenerative conditions, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis, where it helps mitigate neuronal injury by reducing reactive oxygen species and modulating immune responses. Unlike its constitutive isoform HO-2, HO-1 is dynamically regulated and serves as a frontline defense against cellular stress. Deficiency in HO-1 has been linked to increased neuroinflammation, impaired stress tolerance, and heightened vulnerability to neurodegenerative pathology. Given its dual role in detoxifying free heme and generating neuroprotective metabolites, HO-1 is a promising therapeutic target for modulating oxidative stress and inflammation in neurodegenerative disease research.

HSP32, HMOX1, Heme oxygenase 1, HO, HO1, 32 kD, bK286B10, D8Wsu38e, heat shock protein 32 kD, heat shock protein 32kD, Heat shock protein, Heme oxygenase (decycling) 1, Hemox, HMOX 1, Hmox, Hmox1, HMOX1_HUMAN, HO 1, HO-1, Heme Oxygenase-1, Haem Oxygenase-1, Heat Shock Protein 32, Heme Oxygenase (Decyclizing), EC 1.14.14.18

Cancer | Oxidative Stress | Neuroscience | Neurodegeneration | Alzheimer's Disease | Cardiovascular System | Blood | Platelets | Cell Signaling | Epigenetics and Nuclear Signaling | Nuclear Signaling Pathways | NFkB Pathway | Cardiovascular System | Atherosclerosis | Vascular Inflammation | Inflammatory Mediators | Cardiovascular System | Vasculature | Endothelium | Cancer | Cancer Metabolism | Response to Hypoxia | Cell Signaling | Metabolism | Metabolism processes | Hypoxia

1 µg/ml was sufficient for detection of HO-1 in 10 µg of mixed human cell line lysate by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.

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1. Froh M. et al. (2007) World J. Gastroentereol 13 (25) : 3478-86. 2. Elbirt K.K. and Bonkovsky H.L. (1999) Proc Assoc Am Physicians 111 (5) : 348-47. 3. Maines M.D., Trakshel G.M., and Kutty R.K. (1986) J Biol Chem 261: 411–419. 4. Brydun A., et al. (2007) Hypertens Res 30 (4) : 341-8. 5. Poss K.D. and Tonegawa S. (1997) . Proc Natl Acad Sci U S A. 94: 10925–10930. 6. Yet S.F., et al. (2003) FASEB J. 17: 1759–1761. 7. Yachie A., et al. (1999) J Clin Invest. 103: 129–135.