Nurr1 agonist 2

Nurr1 agonist 2 (Compound 7) is a Nurr1 agonist (EC50: 0.07 μM) . Nurr1 agonist 2 binds to the recombinant Nurr1 ligand binding domain (LBD) with a Kd value of 0.14 μM. Nurr1 agonist 2 increases the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2) mRNA expression[1].

Product Specifications

CAS Number

[742058-34-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Nuclear Hormone Receptor 4A/NR4A

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/nurr1-agonist-2.html

Purity

98.03

Solubility

DMSO : 20.83 mg/mL (ultrasonic)

Smiles

OC(C1=CC=C(C2=CC=C(C=C2)OCC3=CC=CC=C3)S1)=O

Molecular Formula

C18H14O3S

Molecular Weight

310.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Ballarotto M, et al.De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime. J Med Chem. 2023 Jun 22;66 (12) :8170-8177.