LP-261
LP-261 is a potent and orally active anti-mitotic agent and shows an inhibition of in vitro tubulin polymerization with an EC50 of 3.2 μM[1]. LP-261 inhibits growth of a human non-small-cell lung tumor (NCI-H522) in vivo and can be used for cancer research[1].
Product Specifications
CAS Number
915412-67-8
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lp-261.html
Purity
99.94
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
CS(=O)(NC1=CC(C(C2=CC(OC)=NC=C2)=O)=CC(C3=CC=CC4=C3C=CN4)=C1)=O
Molecular Formula
C22H19N3O4S
Molecular Weight
421.47
References & Citations
[1]Rupa S Shetty, et al. Synthesis and pharmacological evaluation of N- (3- (1H-indol-4-yl) -5- (2-methoxyisonicotinoyl) phenyl) methanesulfonamide (LP-261), a potent antimitotic agent. J Med Chem. 2011 Jan 13;54 (1) :179-200
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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