Oxotremorine M (iodide)
Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist. Oxotremorine M iodide potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms[1].
Product Specifications
CAS Number
3854-04-4
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/oxotremorine-m-iodide.html
Purity
98.0
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 8.33 mg/mL (ultrasonic)
Smiles
O=C1N(CC#CC[N+](C)(C)C)CCC1.[I-]
Molecular Formula
C11H19IN2O
Molecular Weight
322.19
References & Citations
[1]Zwart R, et al. Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independentmechanisms. Biochem Biophys Res Commun. 2018 Jan 1;495 (1) :481-486.|[2]Tran JA, et al. Differential coupling of muscarinic M1, M2, and M3 receptors to phosphoinositide hydrolysis in urinary bladder and longitudinal muscle of the ileum of the mouse. J Pharmacol Exp Ther. 2006 Aug;318 (2) :649-56. Epub 2006 May 4.|[3]Zwart R, et al. A novel muscarinic receptor-independent mechanism of KCNQ2/3 potassium channel blockadeby Oxotremorine-M. Eur J Pharmacol. 2016 Nov 15;791:221-228.|[4]Ichikawa J, et al. Cholinergic modulation of basal and amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Brain Res. 2002 Dec 20;958 (1) :176-84.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400181-500 1x 500 µL
CD59 (heavy chain of Protectin) (BRA-10G), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740012-500 1x 500 µL
Tyrosinase (T311), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400276-500 1x 500 µL
TAG-72 / CA72.4 (B72.3), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880525-500 1x 500 µL
CD63 (MX-49.129.5), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC682563-500 1x 500 µL
GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2563), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880907-500 1x 500 µL
TTF-1 / NKX2.1 (8G7G3/1 + NX2.1/690), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details