Tiludronate (disodium)

Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H (+) -ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].

Product Specifications

CAS Number

[149845-07-8]

Product Name Alternative

Tiludronic acid (disodium)

UNSPSC

12352005

Hazard Statement

H302, H318

Target

Proton Pump

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tiludronate-disodium.html

Purity

99.97

Solubility

H2O : 62.5 mg/mL (ultrasonic)

Smiles

O=P(O)(O[Na])C(P(O)(O[Na])=O)SC1=CC=C(Cl)C=C1

Molecular Formula

C7H7ClNa2O6P2S

Molecular Weight

362.57

Precautions

H302, H318

References & Citations

[1]Reginster JY, et al. Prevention of postmenopausal bone loss by tiludronate. Lancet. 1989 Dec 23-30;2 (8678-8679) :1469-71.|[2]Nunes NLT, et al. Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats. J Periodontol. 2018 Jan;89 (1) :105-116.|[3]Bonjour JP, et al. Tiludronate: bone pharmacology and safety. Bone. 1995;17 (5 Suppl) :473S-477S.|[4]David P, et al. The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H (+) -ATPase. J Bone Miner Res. 1996;11 (10) :1498-1507.