DOTA-GA-maleimide

DOTA-GA-maleimide is a bifunctional chelator containing a DOTA macrocycle chelator, a GA linker, and a maleimide reactive group. DOTA-GA-maleimide can achieve radiolabeling of proteins by forming a stable coordination complex between the DOTA macrocycle and radioactive metal ions (such as 111In) through the specific binding of maleimide to protein thiol groups. DOTA-GA-maleimide can be used for SPECT imaging studies of MMP activity-related cancers[1][2].

Product Specifications

CAS Number

[1800229-46-2]

UNSPSC

12352005

Target

Biochemical Assay Reagents; MMP; Radionuclide-Drug Conjugates (RDCs)

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dota-ga-maleimide.html

Purity

99.79

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

O=C(CN1CCN(CCN(C(CCC(NCCN2C(C=CC2=O)=O)=O)C(O)=O)CCN(CC1)CC(O)=O)CC(O)=O)O

Molecular Formula

C25H38N6O11

Molecular Weight

598.60

References & Citations

[1]Xavier ME, et al., Pre-labelling versus direct labelling of anthrax proteins for imaging of matrix metalloproteinases activity using DOTA-GA. Nucl Med Biol. 2019 May-Jun;72-73:49-54.|[2]ElSohly AM, et al. Synthetically Modified Viral Capsids as Versatile Carriers for Use in Antibody-Based Cell Targeting. Bioconjug Chem. 2015 Aug 19;26 (8) :1590-6.