ML233
ML233 is a non-peptide based potent apelin receptor (APJ) agonist (EC50=3.7 μM) . ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor (>79 μM) [1].
Product Specifications
CAS Number
[2080311-92-6]
UNSPSC
12352005
Target
Apelin Receptor (APJ)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ml233.html
Purity
99.8
Solubility
DMSO : 15 mg/mL (ultrasonic; warming)
Smiles
O=C(C(C1CCCCC1)=C/2)C=C(C)C2=N/OS(=O)(C3=CC=CC=C3)=O
Molecular Formula
C19H21NO4S
Molecular Weight
359.44
References & Citations
[1]Pasha Khan, et al. National Center for Biotechnology Information; 2011. Functional agonists of the apelin (APJ) receptor. In Probe Reports from the NIH Molecular Libraries Program.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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