CDK12-IN-5
CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM) . CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1) [1].
Product Specifications
CAS Number
[2651200-35-8]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk12-in-5.html
Purity
98.03
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC(C1=C2N(N=C1)C(NCC3=NC4=CC=C(F)C(F)=C4N3)=NC(N5CCOCC5)=N2)(F)F
Molecular Formula
C18H15F5N8O
Molecular Weight
454.36
References & Citations
[1]Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12; CDK2; CDK9
Available Sizes
Curated Selection
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