Alphadolone acetate

Alphadolone acetate (Alfadolone acetate) is a steroid agent that can suppress or relieve pain, with antinociception[1].

Product Specifications

CAS Number

[23930-37-2]

Product Name Alternative

Alfadolone acetate; GR 2/1574

UNSPSC

12352211

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/alphadolone-acetate.html

Purity

98.50

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](O)CC2)([H])[C@@]4([H])[C@@](C)([C@@H](C(COC(C)=O)=O)CC4)CC3=O

Molecular Formula

C23H34O5

Molecular Weight

390.51

References & Citations

[1]Nadeson R, et al. Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA (A) receptors. Pain. 2000 Oct;88 (1) :31-39.|[2]Dyer RG, Mansfield S. Anaesthesia with alphaxalone plus alphadolone acetate blocks the oestrogen-stimulated LH surge and impairs pulsatile LH secretion in ovariectomized female rats. J Endocrinol. 1984 Jul;102 (1) :27-31.|[3]Emanuele MA, et al. Anaesthesia with alphaxalone plus alphadolone acetate decreases serum concentrations of LH in castrated rats. J Endocrinol. 1987 Nov;115 (2) :221-3.