NRPSs-IN-1
NRPSs-IN-1 (Compound 7) is a cell-penetrating inhibitor of non-ribosomal peptide synthetase (NRPSs) . NRPSs-IN-1 K inhibits gramicidin S synthetase A (GrsA) with a Kd value of 16.6 nM[1].
Product Specifications
UNSPSC
12352005
Target
Aminoacyl-tRNA Synthetase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nrpss-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NS(=O)(OC[C@@H]1[C@@H](O)[C@@H](OCC#C)[C@H](N2C(N=CN=C3N)=C3N=C2)O1)=O)[C@@H](N)CC4=CC=CC=C4
Molecular Formula
C22H25N7O7S
Molecular Weight
531.54
References & Citations
[1]Ishikawa F, et al. Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells. Beilstein J Org Chem. 2024 Feb 26;20:445-451.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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