IJak-381
IJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits IL-4 and IL-6 signaling pathways. iJak-381 also reduced p-STAT6 levels and inhibited the influx of inflammatory cells into the lungs of mice. iJak-381 inhibits airway hyperresponsiveness (AHR) [1].
Product Specifications
CAS Number
[1831144-46-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
JAK; STAT
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ijak-381.html
Purity
99.86
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2N=CC=CN2N=C1)NC3=CN(CC(N4CCC(N(CCC#N)C)CC4)=O)N=C3C5=CC(Cl)=CC=C5OC(F)F
Molecular Formula
C28H28ClF2N9O3
Molecular Weight
612.03
Precautions
H302, H315, H319, H335
References & Citations
[1]Zak M, et al. Inhaled Janus Kinase (JAK) inhibitors for the treatment of asthma. Bioorg Med Chem Lett. 2019 Oct 15;29 (20) :126658.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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