AZ-4217
AZ-4217 is an inhibitor for β-site amyloid precursor protein cleavage enzyme 1 (BACE1), with IC50 of 160 pM in human SH-SY5Y cells. AZ-4217 reduces amyloid deposition in Tg2576 mouse models, and is used for Alzheimer’s Disease research[1].
Product Specifications
CAS Number
1383846-83-0
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/az-4217.html
Smiles
O=C(C(C)=C1)N(CC)C=C1[C@@]2(C3=CC(C4=CN=CC(C#CC)=C4)=CC=C3)C5=CC=CC(F)=C5C(N)=N2
Molecular Formula
C30H25FN4O
Molecular Weight
476.54
References & Citations
[1]Eketjäll S, et al., AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. J Neurosci. 2013 Jun 12;33 (24) :10075-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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