2'-OMe-Ac-C Phosphoramidite

2'-OMe-Ac-C Phosphoramidite is a modified phosphoramidite and can be used for the oligonucleotide synthesis. 2'-OMe-Ac-C Phosphoramidite contributes to improving the stability and activity of oligonucleotides[1].

Product Specifications

CAS Number

[199593-09-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis; Drug Intermediate

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-ome-ac-c-phosphoramidite.html

Purity

99.53

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OC)[C@H](N5C(N=C(NC(C)=O)C=C5)=O)O4

Molecular Formula

C42H52N5O9P

Molecular Weight

801.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Ishikawa K, et al. Synthesis and Properties of Gapmer Oligonucleotides Containing 4'-Carboxy- and 4'-Carbamoyl-Thymidine Analogs. Chembiochem. 2025 Jun 16;26 (12) :e202500137.