Phospho-Chk1 (Ser317) Rabbit APC Conjugate

<strong>Phospho-Chk1 (Ser317) Rabbit APC Conjugate </strong>_x000D_ <strong>Catalog number:</strong> B2018512_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 25 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8°C_x000D_ <strong>Keywords:</strong> Serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1, CHEK1_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Bernard JJ, Lou YR, Peng QY, Li T, Conney AH, Lu YP. Inverse relationship between p53 and phospho-Chk1 (Ser317) protein expression in UVB-induced skin tumors in SKH-1 mice Exp Mol Pathol. 2014 Feb;96(1):126-31._x000D_ 2: Lu YP, Lou YR, Peng QY, Nghiem P, Conney AH. Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice Cancer Prev Res (Phila). 2011 Jul;4(7):1118-25._x000D_ 3: Rybaczek D, Kowalewicz-Kulbat M. Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangements Histochem Cell Biol. 2011 Mar;135(3):263-80._x000D_ 4: Okita N, Minato S, Ohmi E, Tanuma S, Higami Y. DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism FEBS Lett. 2012 Nov 16;586(22):3974-9._x000D_ 5: Wang Z, Førsund MS, Trope CG, Nesland JM, Holm R, Slipicevic A. Evaluation of CHK1 activation in vulvar squamous cell carcinoma and its potential as a therapeutic target in vitro Cancer Med. 2018 Aug;7(8):3955-3964._x000D_ 6: Yang H, Huebner K, Hampel C, Erlenbach-Wuensch K, Selvamani SB, Shukla V, Geppert CI, Hartmann A, Mahadevan V, Schneider-Stock R. ATF2 loss promotes 5-FU resistance in colon cancer cells via activation of the ATR-Chk1 damage response pathway BMC Cancer. 2023 May 27;23(1):480._x000D_ 7: Ikegami Y, Goto H, Kiyono T, Enomoto M, Kasahara K, Tomono Y, Tozawa K, Morita A, Kohri K, Inagaki M. Chk1 phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication and damage checkpoint stimulation Biochem Biophys Res Commun. 2008 Dec 26;377(4):1227-31._x000D_ 8: Shiromizu T, Goto H, Tomono Y, Bartek J, Totsukawa G, Inoko A, Nakanishi M, Matsumura F, Inagaki M. Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1) Genes Cells. 2006 May;11(5):477-85._x000D_ 9: Su B, Lim D, Qi C, Zhang Z, Wang J, Zhang F, Dong C, Feng Z. VPA mediates bidirectional regulation of cell cycle progression through the PPP2R2A-Chk1 signaling axis in response to HU Cell Death Dis. 2023 Feb 13;14(2):114._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/21440578">10: Kim AJ, Kim HJ, Jee HJ, Song N, Kim M, Bae YS, Chung JH, Yun J. Glucose deprivation is associated with Chk1 degradation through the ubiquitin-proteasome pathway and effective checkpoint response to replication blocks Biochim Biophys Acta. 2011 Jun;1813(6):1230-8. </a>_x000D_ _x000D_ <strong>Products Related to Phospho-Chk1 (Ser317) Rabbit APC Conjugate can be found at</strong> <a href="https://moleculardepot.com/product-category/Conjugates/"> Conjugates</a>