3-Methyladenine (Standard)

3-Methyladenine (Standard) is the analytical standard of 3-Methyladenine. This product is intended for research and analytical applications. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K[1].

Product Specifications

CAS Number

[5142-23-4]

Product Name Alternative

3-MA (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Endogenous Metabolite; Mitophagy; PI3K; Reference Standards

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/3-methyladenine-standard.html

Purity

99.97

Smiles

NC1=C2N=CN=C2N(C)C=N1

Molecular Formula

C6H7N5

Molecular Weight

149.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6 (6) :805-7.|[2]Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 2012;7 (4) :e35665.|[3]Wang X, et al. Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats.Mediators Inflamm. 2016;2016:8369704.