Abemaciclib (Standard)

Abemaciclib (Standard) is the analytical standard of Abemaciclib. This product is intended for research and analytical applications. Abemaciclib (LY2835219) is a selective CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively.

Product Specifications

CAS Number

[1231929-97-7]

Product Name Alternative

LY2835219 (Standard)

UNSPSC

12352005

Hazard Statement

H360, H373, H410

Target

CDK; Reference Standards

Type

Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/abemaciclib-standard.html

Purity

99.94

Smiles

CC1=NC2=C(F)C=C(C3=NC(NC4=NC=C(CN5CCN(CC)CC5)C=C4)=NC=C3F)C=C2N1C(C)C

Molecular Formula

C27H32F2N8

Molecular Weight

506.59

Precautions

H360, H373, H410

References & Citations

[1]Ku BM, et al. The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma. Oncotarget.?2016 Mar 22;7 (12) :14803-13.|[2]Yadav V, et al. The CDK4/6 inhibitor LY2835219 overcomes PLX4032 resistance resulting from MAPK reactivation and cyclin D1 upregulation. Mol Cancer Ther. 2014 Oct;13 (10) :2253-63.|[3]Gelbert LM, et al. Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with NSC 613327. Invest New Drugs. 2014 Oct;32 (5) :825-37.