(-) BI97D6

(-) BI97D6 is a broad-spectrum inhibitor of the Bcl-2 protein family, inhibiting Mcl-1, Bcl-2, Bcl-xL and Bcl-1 with IC50 values of 0.025, 0.031, 0.076 and 0.122 μM, respectively. (-) BI97D6 stimulates cell death through the Bak and Bax mediated mitochondrial apoptosis pathway. In addition, (-) BI97D6 inhibits Mcl-1 and can effectively induce apoptosis in acute myeloid leukemia (AML) cells[1].

Product Specifications

CAS Number

[1430067-36-9]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/minus-bi97d6.html

Smiles

O=C1C2=CC(O)=C(C(CC3=CC=CC=C3)=C2C(C(C)=C1C(C(C4=CC(O)=C(C(CC5=CC=CC=C5)=C46)O)=O)=C(C)C6=O)=O)O

Molecular Formula

C36H26O8

Molecular Weight

586.59

References & Citations

[1]Rongqing Pan, et al. "Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–) BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia." Blood, The Journal of the American Society of Hematology 126.3 (2015) : 363-372.