Ambroxol (Standard)

Ambroxol (Standard) is the analytical standard of Ambroxol. This product is intended for research and analytical applications. Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].

Product Specifications

CAS Number

[18683-91-5]

Product Name Alternative

NA-872 (Standard)

UNSPSC

12352005

Target

Autophagy; Glycosidase; Reference Standards

Type

Reference Standards

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ambroxol-standard.html

Smiles

O[C@H]1CC[C@H](NCC2=CC(Br)=CC(Br)=C2N)CC1

Molecular Formula

C13H18Br2N2O

Molecular Weight

378.10

References & Citations

[1]Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15 (3) :213-218.|[2]Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80 (5) :766-775.