Levistolide A

Levistolide A is an apoptosis inducer and a PEDV virus inhibitor. Levistolide A can induce apoptosis in colon cancer cells and suppress the replication of porcine epidemic diarrhea virus (PEDV) by promoting ROS generation. Levistolide A activates peroxisome proliferator-activated receptor γ (PPARγ) in N2a/APP695swe cells and reduces excessive phosphorylation of tau through the GSK3α/β pathway, improving symptoms in Alzheimer’s mice. Levistolide A improves kidney damage in 5/6 nephrectomy (Nx) mice by inhibiting the RAS, TGF-β1/Smad, and MAPK pathways[1][2][3][4].

Product Specifications

CAS Number

[88182-33-6]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; GSK-3; PPAR; Ras; Reactive Oxygen Species (ROS) ; Tau Protein; TGF-β Receptor

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/levistolide-a.html

Purity

99.34

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O/C([C@@]1(CC2)[C@]34[H])=C\CCC)C1=C[C@]2([H])[C@]3([H])CCC5=C4C(O/C5=C\CCC)=O

Molecular Formula

C24H28O4

Molecular Weight

380.48

Precautions

H302

References & Citations

[1]Yang Y, et al. Levistolide A Induces Apoptosis via ROS-Mediated ER Stress Pathway in Colon Cancer Cells. Cell Physiol Biochem. 2017;42 (3) :929-938. |[2]Qu X, et al. Levistolide A Attenuates Alzheimer's Pathology Through Activation of the PPARγ Pathway. Neurotherapeutics. 2021 Jan;18 (1) :326-339. |[3]Zeng W, et al. Levistolide A Inhibits PEDV Replication via Inducing ROS Generation. Viruses. 2022 Jan 27;14 (2) :258. |[4]Aobulikasimu N, et al. Levistolide A ameliorates fibrosis in chronic kidney disease via modulating multitarget actions in vitro and in vivo. Life Sci. 2023 May 1;320:121565.