Cemdisiran

Cemdisiran is an N-acetylgalactosamine (GalNAc) conjugated siRNA for the research of complement-mediated diseases by suppressing liver production of complement 5 (C5) protein.

Product Specifications

CAS Number

[1639264-46-2]

Product Name Alternative

ALN-CC5

UNSPSC

12352208

Target

Complement System; Small Interfering RNA (siRNA)

Type

Oligonucleotides

Related Pathways

Epigenetics; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/cemdisiran.html

Purity

95.24

Solubility

H2O : ≥ 20 mg/mL

Smiles

[Cemdisiran]

Molecular Formula

C542H711F17N169O330P45S6

Molecular Weight

16782.53

References & Citations

[1]Badri P, Jiang X, Borodovsky A, et al. Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria. Clin Pharmacokinet. 2021;60 (3) :365-378.|[2]Prajakta Badri, et al. Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria. Clin Pharmacokinet. 2021;60 (3) :365-378.