MIRA-1
MIRA-1 is a maleimide analogue. MIRA-1 can induce apoptosis in mutant p53 cells via restoration of p53-dependent transcriptional transactivation. MIRA-1 has anticancer activity[1].
Product Specifications
CAS Number
[72835-26-8]
Product Name Alternative
NSC 19630
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mira-1.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C=C1)N(COC(CC)=O)C1=O
Molecular Formula
C8H9NO4
Molecular Weight
183.16
Precautions
H301, H311, H331, H341
References & Citations
[1]Bykov VJ, et al. Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs [published correction appears in J Biol Chem. 2017 Dec 1;292 (48) :19607]. J Biol Chem. 2005;280 (34) :30384-30391.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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