MIRA-1

MIRA-1 is a maleimide analogue. MIRA-1 can induce apoptosis in mutant p53 cells via restoration of p53-dependent transcriptional transactivation. MIRA-1 has anticancer activity[1].

Product Specifications

CAS Number

[72835-26-8]

Product Name Alternative

NSC 19630

UNSPSC

12352005

Hazard Statement

H301, H311, H331, H341

Target

Apoptosis; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mira-1.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C=C1)N(COC(CC)=O)C1=O

Molecular Formula

C8H9NO4

Molecular Weight

183.16

Precautions

H301, H311, H331, H341

References & Citations

[1]Bykov VJ, et al. Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs [published correction appears in J Biol Chem. 2017 Dec 1;292 (48) :19607]. J Biol Chem. 2005;280 (34) :30384-30391.