DZD1516
DZD1516 is a potent and selective HER2 inhibitor (IC50=0.56 nM) with good blood-brain permeability. DZD1516 exhibits antitumor activity in CNS and subcutaneous xenograft mouse models[1].
Product Specifications
CAS Number
[2387570-00-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dzd1516.html
Purity
98.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC2=C(C(NC3=CC=C(C(C)=C3)OC4=CC5=NC=NN5C=C4)=NC=N2)C(O[C@H]6CCN(CC6(F)F)C)=C1
Molecular Formula
C28H27F2N7O3
Molecular Weight
547.56
Precautions
H302, H315, H319
References & Citations
[1]Zhang J, et al. Preclinical and clinical activity of DZD1516, a full blood-brain barrier-penetrant, highly selective HER2 inhibitor. Breast Cancer Res. 2023 Jul 6;25 (1) :81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6004850-01 0.2 mL
MYCBP, NT (MYCBP, AMY1, C-Myc-binding protein, Associate of Myc 1)
Ask
View Details 
MBS6004850-02 5x 0.2 mL
MYCBP, NT (MYCBP, AMY1, C-Myc-binding protein, Associate of Myc 1)
Ask
View Details