Prosapogenin A

Prosapogenin A, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis[1].

Product Specifications

CAS Number

[19057-67-1]

Product Name Alternative

Progenin III

UNSPSC

12352005

Target

Apoptosis; Caspase; Pyroptosis; STAT

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/prosapogenin-a.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@@H](C)CO4)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6(C(C[C@@H](O[C@@]7([H])[C@@H]([C@H]([C@H](O)[C@@H](CO)O7)O)O[C@@]8([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O8)O)O)CC6)=CC5)C)([H])CC2

Molecular Formula

C39H62O12

Molecular Weight

722.90

References & Citations

[1]Wang TX, et al. Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis. Oncol Lett. 2013 Nov;6 (5) :1323-1328.|[2]Liu Y, et al., Prosapogenin A induces GSDME-dependent pyroptosis of anaplastic thyroid cancer through vacuolar ATPase activation-mediated lysosomal over-acidification. Cell Death Dis. 2024 Aug 13;15 (8) :586.