Vedaprofen

Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition [1]. Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM[2].

Product Specifications

CAS Number

[71109-09-6]

Product Name Alternative

Quadrisol; CERM 10202; PM 150

UNSPSC

12352005

Hazard Statement

H302

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vedaprofen.html

Purity

99.42

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(C1=CC=C(C2CCCCC2)C3=C1C=CC=C3)C(O)=O

Molecular Formula

C19H22O2

Molecular Weight

282.38

Precautions

H302

References & Citations

[1]P Lees, et al. PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology. J Vet Pharmacol Ther. 2004 Dec;27 (6) :491-502.|[2]Zhou Yin, et al. DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs. Chem Biol. 2014 Apr 24;21 (4) :481-487.|[3]M Hoeijmakers, et al. The pharmacokinetics of Vedaprofen and its enantiomers in dogs after single and multiple dosing. J Vet Pharmacol Ther. 2005 Jun;28 (3) :305-12.