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N- (Azido-PEG3) -N- (PEG2-amine) -PEG3-acid

N- (Azido-PEG3) -N- (PEG2-amine) -PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N- (Azido-PEG3) -N- (PEG2-amine) -PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

2183440-70-0

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-azido-peg3-n-peg2-amine-peg3-acid.html

Purity

99.58

Solubility

10 mM in DMSO

Smiles

O=C(O)CCOCCOCCOCCN(C(CCOCCOCCN)=O)CCOCCOCCOCCN=[N+]=[N-]

Molecular Formula

C24H47N5O11

Molecular Weight

581.66

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Available Sizes

Frequently Asked Questions

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