DREADD agonist 21
DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC50=1.7 nM) [1].
Product Specifications
CAS Number
[56296-18-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/DREADD-agonist-21.html
Purity
99.46
Solubility
DMSO : ≥ 78 mg/mL
Smiles
C12=CC=CC=C1NC3=CC=CC=C3C(N4CCNCC4)=N2
Molecular Formula
C17H18N4
Molecular Weight
278.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Chen X, et al. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem Neurosci. 2015 Mar 18;6 (3) :476-84.|[2]Thompson KJ, et al. DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo. ACS Pharmacol Transl Sci. 2018 Sep 14;1 (1) :61-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR3
Citation 01
Brain Res Bull. 2021 Aug:173:66-73.|bioRxiv. 2025 Oct 9.
Available Sizes
Curated Selection
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