Factor VIIa Substrate

<strong>Factor VIIa Substrate</strong>_x000D_ <strong>Catalog number:</strong> B2013011_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 2 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 644.8 g/mol_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> MeSO2-Cha-Abu-Arg-AFC_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Birkle F, Morrissey JH. A serine loop in tissue factor mediates substrate selectivity by the tissue factor-factor VIIa complex J Thromb Haemost. 2021 Jan;19(1):75-84._x000D_ 2: Gajsiewicz JM, Morrissey JH. Structure-Function Relationship of the Interaction between Tissue Factor and Factor VIIa Semin Thromb Hemost. 2015 Oct;41(7):682-90._x000D_ 3: Persson E, Olsen OH. Current status on tissue factor activation of factor VIIa Thromb Res. 2010 Apr;125 Suppl 1:S11-2._x000D_ 4: Sichler K, Banner DW, D'Arcy A, Hopfner KP, Huber R, Bode W, Kresse GB, Kopetzki E, Brandstetter H. Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions J Mol Biol. 2002 Sep 20;322(3):591-603._x000D_ 5: Shobe J, Dickinson CD, Edgington TS, Ruf W. Macromolecular substrate affinity for the tissue factor-factor_VIIa complex is independent of scissile bond docking J Biol Chem. 1999 Aug 20;274(34):24171-5._x000D_ 6: Butenas S, Lawson JH, Kalafatis M, Mann KG. Cooperative interaction of divalent metal ions, substrate, and tissue factor with factor VIIa Biochemistry. 1994 Mar 22;33(11):3449-56._x000D_ 7: Ruf W, Shobe J, Rao SM, Dickinson CD, Olson A, Edgington TS. Importance of factor_VIIa Gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X Gla-domain Biochemistry. 1999 Feb 16;38(7):1957-66._x000D_ 8: Higashi S, Nishimura H, Fujii S, Takada K, Iwanaga S. Tissue factor potentiates the factor_VIIa-catalyzed hydrolysis of an ester substrate J Biol Chem. 1992 Sep 5;267(25):17990-6._x000D_ 9: Larsen KS, Ostergaard H, Olsen OH, Bjelke JR, Ruf W, Petersen LC. Engineering of substrate selectivity for tissue factor.factor VIIa complex signaling through protease-activated receptor 2 J Biol Chem. 2010 Jun 25;285(26):19959-66._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/17182039">10: Bjelke JR, Persson E, Rasmussen HB, Kragelund BB, Olsen OH. A loop of coagulation factor VIIa influencing macromolecular substrate specificity FEBS Lett. 2007 Jan 9;581(1):71-6. </a>_x000D_ _x000D_ <strong>Products Related to Factor VIIa Substrate can be found at</strong> <a href="https://moleculardepot.com/product-category/Substrates/"> Substrates</a>