1-Methylxanthine

1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP) [1]. 1-Methylxanthine enhances the radiosensitivity of tumor cells[2].

Product Specifications

CAS Number

[6136-37-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite; Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-methylxanthine.html

Concentration

10mM

Purity

99.46

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1C)NC2=C(N=CN2)C1=O

Molecular Formula

C6H6N4O2

Molecular Weight

166.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Algharrawi KH, et al. Direct conversion of theophylline to 3-methylxanthine by metabolically engineered E. coli. Microb Cell Fact. 2015 Dec 21;14:203.|[2]Youn H, et al. 1-Methylxanthine enhances the radiosensitivity of tumor cells. Int J Radiat Biol. 2009 Feb;85 (2) :167-74.