TL12-186

TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM) [1].

Product Specifications

CAS Number

[2250025-88-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

CDK; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tl12-186.html

Purity

99.63

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(NCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)C=C2)CC1)CNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O

Molecular Formula

C44H51ClN10O9S

Molecular Weight

931.46

Precautions

H315, H319, H320

References & Citations

[1]Hai-Tsang Huang, et al. A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. Cell Chem Biol. 2018 Jan 18;25 (1) :88-99.e6.