GSK2879552 (dihydrochloride)
GSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity[1][2].
Product Specifications
CAS Number
[1902123-72-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk2879552-dihydrochloride.html
Concentration
10mM
Purity
99.82
Solubility
DMSO : 31.25 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(CN2CCC(CN[C@H]3[C@H](C4=CC=CC=C4)C3)CC2)C=C1.[H]Cl.[H]Cl
Molecular Formula
C23H30Cl2N2O2
Molecular Weight
437.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Huang M, et al. Targeting KDM1A attenuates Wnt/β-catenin signaling pathway to eliminate sorafenib-resistant stem-like cells in hepatocellular carcinoma. Cancer Lett. 2017 Apr 2;398:12-21.|[2]Mohammad HP, et al. A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28 (1) :57-69.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
KDM1/LSD1
Citation 01
Clin Exp Med. 2025 Nov 25;26 (1) :33.|Acta Pharmacol Sin. 2022 Feb;43 (2) :457-469.|Bioorg Chem. 2024 Jul 1:150:107603.|bioRxiv. 2024 Dec 23:2024.12.23.630174.|Cancer Chemother Pharmacol. 2019 Feb;83 (2) :277-287.|Cell Rep. 2022 Dec 6;41 (10) :111770.|Cytokine. 2022 Mar:151:155789.|Eur J Med Chem. 2024 Aug 28:278:116801.|Eur J Pharmacol. 2024 Aug 23:176931.|J Endocrinol. 2019 Sep 1; JOE-19-0188.R1.|Mol Cancer Res. 2022 Feb;20 (2) :217-230.|Mol Carcinog. 2023 Aug;62 (8) :1119-1135.|Mol Cell Biochem. 2025 Oct 15.|Mol Cell. 2023 Dec 7;83 (23) :4370-4385.e9.|Nat Chem Biol. 2025 Feb;21 (2) :227-237.|Nat Commun. 2021 Nov 24;12 (1) :6831.|Nat Commun. 2024 May 21;15 (1) :4327.|Natl Sci Rev. 2023 Feb 14;10 (4) :nwad028.
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