Esculin (sesquihydrate)

Esculin sesquihydrate, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin sesquihydrate ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti oxidative stress and anti inflammatory effects, via the MAPK signaling pathway[1][2].

Product Specifications

CAS Number

[66778-17-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

P38 MAPK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/esculin-sesquihydrate.html

Concentration

10mM

Purity

98.80

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=CC2=CC(O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)=C(O)C=C2O1.O.[3/2]

Molecular Formula

C15H16O9.3/2H2O

Molecular Weight

367.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Knox K, et al. The Coumarin Glucoside, Esculin, Reveals Rapid Changes in Phloem-Transport Velocity in Response to Environmental Cues. Plant Physiol. 2018 Oct;178 (2) :795-807.|[2]Song Y, et al. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway. Mol Med Rep. 2018 May;17 (5) :7395-7402.