VEGFR-2/AKT-IN-1

VEGFR-2/AKT-IN-1 (compound 17) is a dual inhibitor of VEGFR-2 and AKT, with the IC50s of 0.164 μM and 0.452 μM, respectively. VEGFR-2/AKT-IN-1 has antitumor activity[1].

Product Specifications

UNSPSC

12352005

Target

Akt; VEGFR

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-2-akt-in-1.html

Smiles

NC1=C(C2=NN=C(NC(C3=CC=CC=C3)=O)S2)SC4=C1C5=NC(N)=NN5C=N4

Molecular Formula

C16H11N9OS2

Molecular Weight

409.45

References & Citations

[1]Heba K Abd El-Mawgoud, et al. Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers. Bioorg Chem. 2024 Sep:150:107622.