MKI-1

MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC50 of 9.9 μM, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer[1].

Product Specifications

CAS Number

[1190277-80-5]

Product Name Alternative

MASTL Kinase Inhibitor-1

UNSPSC

12352005

Target

MASTL

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mki-1.html

Purity

98.07

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=NC2=CC=CC=C2N1)C3=CC=CC(N4C=CC=C4)=C3

Molecular Formula

C18H14N4O

Molecular Weight

302.33

References & Citations

[1]Ah-Young Kim, et al. MKI-1, a Novel Small-Molecule Inhibitor of MASTL, Exerts Antitumor and Radiosensitizer Activities Through PP2A Activation in Breast cancer. Front Oncol. 2020 Sep 29;10:571601.