Keap1-Nrf2-IN-24
Keap1-Nrf2-IN-24 (compound 57) is a potent Keap1-Nrf2 inhibitor with a Ki value of 13 nM. Keap1-Nrf2-IN-24 increases the protein expression of TRXR1 and NQO1. Keap1-Nrf2-IN-24 increases the AKR1B10 mRNA expression. Keap1-Nrf2-IN-24 shows good metabolic stability[1].
Product Specifications
UNSPSC
12352101
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-24.html
Smiles
O=C(C(NC(C1=CC=CC2=C1C3=C(C=CC=C3)N2C)=O)C4=CC5=C(CCN(C5)S(=O)(C6=CC=C(C(C#N)=C6)F)=O)C=C4)O
Molecular Formula
C32H25FN4O5S
Molecular Weight
596.63
References & Citations
[1]Qin Y, et al. Structure-Guided Conformational Restriction Leading to High-Affinity, Selective, and Cell-Active Tetrahydroisoquinoline-Based Noncovalent Keap1-Nrf2 Inhibitors. J Med Chem. 2024 Oct 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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