Heme Oxygenase-1-IN-3

Heme Oxygenase-1-IN-3 (compound 4) is a highly selective heme oxygenase-1 (HO-1) inhibitor (Kd=141 nM) that can be used in the research of cancer and neurodegenerative diseases[1].

Product Specifications

CAS Number

[1043712-39-5]

UNSPSC

12352101

Target

Heme Oxygenase (HO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/heme-oxygenase-1-in-3.html

Smiles

O=S(NCCNC1=NC(C2=CC(Br)=CC=C2)=NC3=CC=CC=C31)(C4=CC=C(F)C=C4)=O

Molecular Formula

C22H18BrFN4O2S

Molecular Weight

501.37

References & Citations

[1]Shuai Han, et al. Highly Selective Novel Heme Oxygenase-1 Hits Found by DNA-Encoded Library Machine Learning beyond the DEL Chemical Space. ACS Medicinal Chemistry Letters (2024) .