EF-4-177

EF-4-177 is an orally active and allosteric CDK2 inhibitor with the IC50 of 87 nM. EF-4-177 can disrupt spermatogenesis[1][2].

Product Specifications

CAS Number

[2891574-93-7]

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ef-4-177.html

Smiles

N#CC1=CC2=C(C(CCNC3=C(C=C(C=C3)S(F)(F)(F)(F)F)C(O)=O)=CN2)C=C1

Molecular Formula

C18H14F5N3O2S

Molecular Weight

431.38

References & Citations

[1]Faber EB, et al. Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J Med Chem. 2023;66 (3) :1928-1940. |[2]Huang Y, et al. Targeting cyclin-dependent kinases: From pocket specificity to drug selectivity. Eur J Med Chem. Published online May 29, 2024.