Quinine (sulfate)

Quinidine sulfate is an antiarrhythmic agent. Quinidine sulfate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate is also a K+ channel blocker with an IC50 of 19.9 μM. Quinidine sulfate can be used for malaria research[1][2][3].

Product Specifications

CAS Number

[549-56-4]

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H335

Target

Cytochrome P450; Parasite; Potassium Channel

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/quinine-sulfate.html

Purity

97.0

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O[C@H](C1=CC=NC2=C1C=C(OC)C=C2)[C@@]3([H])[N@](C[C@@H]4C=C)CC[C@H]4C3.O=S(O)(O)=O

Molecular Formula

C20H26N2O6S

Molecular Weight

422.50

Precautions

H315, H317, H319, H335

References & Citations

[1]Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103 (3) :1807-13.|[2]Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide.|[3]Moody DE, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol. 1990 Sep-Oct;14 (5) :311-7.