Fmoc-Val-Ala-PAB-PNP
Fmoc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[1394238-92-6]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fmoc-val-ala-pab-pnp.html
Purity
98.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[O-][N+](C(C=C1)=CC=C1OC(OCC(C=C2)=CC=C2NC([C@H](C)NC([C@H](C(C)C)NC(OCC3C4=CC=CC=C4C5=CC=CC=C53)=O)=O)=O)=O)=O
Molecular Formula
C37H36N4O9
Molecular Weight
680.70
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Protease Cleavable Linker
Available Sizes
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