Naspm
Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
Product Specifications
CAS Number
[122306-11-0]
Product Name Alternative
1-Naphthylacetyl spermine
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Naspm.html
Purity
96.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1
Molecular Formula
C22H34N4O
Molecular Weight
370.53
References & Citations
[1]Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29 (1) :27-36.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor
Citation 01
Cell Rep. 2023 Dec 3;42 (12) :113551.|iScience. 2023 Mar 3;26 (4) :106322.|J Headache Pain. 2022 Aug 10;23 (1) :98.|Neurobiol Dis. 2024 May:194:106471.|Neuroscience. 2021 Nov 1:475:220-228.|Toxicol In Vitro. 2017 Oct:44:57-65.|Cell Rep. 2020 Nov 10;33 (6) :108369.
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