Azetukalner
Azetukalner (XEN1101) is a selective and orally active Kv7.2/Kv7.3 potassium channel opener with an EC50 of 27 nM. Azetukalner is approximately 4-fold more selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50 of 94 nM) and Kv7.4 (EC50 of 113 nM) channels. Azetukalner exhibits a selectivity >100-fold for Kv7 channels over other ion channels and receptors. Azetukalner can be used for the study of focal epilepsy[1][2].
Product Specifications
CAS Number
1009344-33-5
Product Name Alternative
XEN1101
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kcnq2-3-activator-1.html
Concentration
10mM
Purity
99.61
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(CC(C)(C)C)NC1=C(C)C=C(N2CC3=CC=C(C=C3CC2)F)C=C1C
Molecular Formula
C23H29FN2O
Molecular Weight
368.49
Precautions
H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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