Azetukalner

Azetukalner (XEN1101) is a selective and orally active Kv7.2/Kv7.3 potassium channel opener with an EC50 of 27 nM. Azetukalner is approximately 4-fold more selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50 of 94 nM) and Kv7.4 (EC50 of 113 nM) channels. Azetukalner exhibits a selectivity >100-fold for Kv7 channels over other ion channels and receptors. Azetukalner can be used for the study of focal epilepsy[1][2].

Product Specifications

CAS Number

[1009344-33-5]

Product Name Alternative

XEN1101

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/kcnq2-3-activator-1.html

Concentration

10mM

Purity

99.61

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(CC(C)(C)C)NC1=C(C)C=C(N2CC3=CC=C(C=C3CC2)F)C=C1C

Molecular Formula

C23H29FN2O

Molecular Weight

368.49

Precautions

H315, H319

References & Citations

[1]Bialer M, et al. Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV) . I. Drugs in preclinical and early clinical development. Epilepsia. 2020 Nov;61 (11) :2340-2364. |[2]Bialer M, et al. Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV) . I. Drugs in preclinical and early clinical development. Epilepsia. 2018 Oct;59 (10) :1811-1841.