DHODH-IN-1

DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway[1].

Product Specifications

CAS Number

[1800296-63-2]

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dhodh-in-1.html

Purity

98.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=CC(C2CC2)=CN=C1N3N=C(OC(C)C)C(OC4=C(F)C=CC=C4F)=C3C

Molecular Formula

C21H20F3N3O2

Molecular Weight

403.40

References & Citations

[1]Lucas-Hourani M, et al.Original 2- (3-Alkoxy-1H-pyrazol-1-yl) azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH) .J Med Chem. 2015 Jul 23;58 (14) :5579-98.