SEC inhibitor KL-1

SEC inhibitor KL-1 (KL-1) is a peptide-like lead compound that is an effective selective SEC inhibitor. SEC inhibitor KL-1 promotes apoptosis and has anti-tumor activity. SEC inhibitor KL-1 doses dependently inhibits the AFF4-CCNT1 interaction, with a Ki value of 3.48 μM[1][2].

Product Specifications

CAS Number

[900308-84-1]

Product Name Alternative

KL-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sec-inhibitor-kl-1.html

Purity

99.58

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

O=C(/C(O)=C/C(C1=CC=CC(OC)=C1)=O)NC2=CC(Cl)=CC=C2C

Molecular Formula

C18H16ClNO4

Molecular Weight

345.78

Precautions

H302, H315, H319, H335

References & Citations

[1]Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175 (3) :766-779.|[2]Hiroaki Katagi, et al. Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma. Neuro Oncol. 2021 Aug 2;23 (8) :1348-1359.